Article
The genetic dissection of essential hypertension.
Nature reviews. Genetics - 1 Nov 2006
Cowley Allen W
Abstract excerpt
QTL mapping in humans and rats has identified hundreds of blood-pressure-related phenotypes and genomic regions; the next daunting task is gene identification and validation. The development of novel rat model systems that mimic many elements of the human disease, coupled with advances in the genomic and informatic infrastructure for rats, promise to revolutionize the hunt for genes that determine susceptibility...
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