Article
[Clinical molecular genetics for PARK8 (LRRK2)].
Brain and nerve = Shinkei kenkyu no shinpo - 1 Aug 2007
Tomiyama Hiroyuki, Hatano Taku, Hattori Nobutaka
Abstract excerpt
Parkinson's disease (PD) is an etiologically heterogeneous disorder characterized by parkinsonism (bradykinesia, resting tremor, rigidity, and postural instability) with good response to L-dopa. PD is the second most prevalent neurodegenerative disorder after Alzheimer disease. Although the majority of PD cases are sporadic, 5-10% of PD is monogenic form of PD as familial PD (FPD). Multifactorial...
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