Overview of the Impact of Pathogenic LRRK2 Mutations in Parkinson's Disease.

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) is a large protein kinase that physiologically phosphorylates and regulates the function of several Rab proteins. LRRK2 is genetically implicated in the pathogenesis of both familial and sporadic Parkinson's disease (PD), although the underlying mechanism is not well understood. Several pathogenic mutations in the LRRK2 gene have been identified, and in most cases the clinical...

Topics

• Humans
• Parkinson Disease
• Protein Serine-Threonine Kinases
• Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
• Mutation
• Lewy Bodies