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Article

Dopaminergic polymorphisms associated with time-on-task declines and fatigue in the Psychomotor Vigilance Test.

PloS one - 1 Jan 2012

Lim Julian, Ebstein Richard, Tse Chun-Yu, Monakhov Mikhail, Lai Poh San, Dinges David F, Kwok Kenneth

Abstract excerpt

Prolonged demands on the attention system can cause a decay in performance over time known as the time-on-task effect. The inter-subject differences in the rate of this decline are large, and recent efforts have been made to understand the biological bases of these individual differences. In this study, we investigate the genetic correlates of the time-on-task effect, as well as its accompanying changes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dopamine Plasma Membrane Transport Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 22438994
DOI: 10.1371/journal.pone.0033767
PMCID: PMC3306301

Genes

COMT
DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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