Article
Testing haplotype-environment interactions using case-parent triads.
Human heredity - 1 Jan 2010
Shi Min, Umbach David M, Weinberg Clarice R
Abstract excerpt
OBJECTIVE: Joint analysis of multiple SNP markers can be informative, but studying joint effects of haplotypes and environmental exposures is challenging. Population structure can involve both genes and exposures and a case-control study is susceptible to bias from either source of stratification. We propose a procedure that uses case-parent triad data and, though not fully robust, resists bias from population...
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