Article
Distinguishing the effects of maternal and offspring genes through studies of "case-parent triads".
American journal of epidemiology - 1 Nov 1998
Wilcox A J, Weinberg C R, Lie R T
Abstract excerpt
A gene variant that increases disease risk will be overrepresented among diseased persons, even compared with their own biologic parents. This insight has led to tests based solely on the asymmetric distribution of a variant allele among cases and their parents (e.g., the transmission/disequilibr...
Topics
- 5,10-Methylenetetrahydrofolate Reductase (FADH2)
- Alleles
- Case-Control Studies
- Computer Simulation
- Congenital Abnormalities
- Female
- Genetic Markers
- Genotype
- Humans
- Likelihood Functions
- Linkage Disequilibrium
- Maternal-Fetal Exchange
- Methylenetetrahydrofolate Reductase (NADPH2)
- Oxidoreductases
- Pregnancy
- Risk Factors