Distinguishing the effects of maternal and offspring genes through studies of "case-parent triads".

Abstract excerpt

A gene variant that increases disease risk will be overrepresented among diseased persons, even compared with their own biologic parents. This insight has led to tests based solely on the asymmetric distribution of a variant allele among cases and their parents (e.g., the transmission/disequilibrium test). Existing methods focus on effects of alleles that operate through the offspring genotype. Alleles can also...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Case-Control Studies
• Share to Computer Simulation