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Article

Using cases and parents to study multiplicative gene-by-environment interaction.

American journal of epidemiology - 1 Aug 2009

Kistner Emily O, Shi Min, Weinberg Clarice R

Abstract excerpt

With case-parent triads, one can estimate genotype relative risks by measuring the apparent overtransmission of susceptibility genotypes from parents to affected offspring. Results obtained using such designs, properly analyzed, resist both bias due to population structure and bias due to self-selection. Most diseases are not purely genetic, and environmental cofactors can also be important. In this paper, the...

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Identifiers

PMID: 19483188
DOI: 10.1093/aje/kwp118
PMCID: PMC2733309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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