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Article

A hybrid design: case-parent triads supplemented by control-mother dyads.

Genetic epidemiology - 1 Feb 2009

Vermeulen Sita H, Shi Min, Weinberg Clarice R, Umbach David M

Abstract excerpt

Hybrid designs arose from an effort to combine the benefits of family-based and population-based study designs. A recently proposed hybrid approach augments case-parent triads with population-based control-parent triads, genotyping everyone except the control offspring. Including parents of controls substantially improves statistical efficiency for testing and estimating both offspring and maternal genetic...

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Identifiers

PMID: 18759250
DOI: 10.1002/gepi.20365
PMCID: PMC2819841

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