Adjusting for spurious gene-by-environment interaction using case-parent triads.

Abstract excerpt

In the case-parent trio design, unrelated children affected with a disease are genotyped along with their parents. Information may also be collected on environmental factors in the children. The design permits estimation and testing of genetic effects and gene-by-environment interaction. Recently, it has been demonstrated that when genotypes are measured at a non-causal test locus, population stratification...

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