Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Case-parent triads: estimating single- and double-dose effects of fetal and maternal disease gene haplotypes.

Annals of human genetics - 1 May 2006

Gjessing H K, Lie R T

Abstract excerpt

Case-parent triad data are considered a robust basis for studying association between variants of a gene and a disease. Methods evaluating statistical significance of association, like the TDT-test and its extensions, are frequently used. When there are prior hypotheses of a causal effect of the gene under study, however, methods measuring penetrance of alleles or haplotypes as relative risks will be more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cleft Lip
Share to Cleft Palate
Share to Fetal Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Linear Models

Share to MSX1 Transcription Factor

Share to Prenatal Diagnosis

Source

Identifiers

PMID: 16674560
DOI: 10.1111/j.1529-8817.2005.00218.x

Genes

MSX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Case-parent triads: estimating single- and double-dose effects of fetal and maternal disease gene haplotypes.PMID 16674560Read ↗

Testing haplotype-environment interactions using case-parent triads.Semantic proximity Read ↗

Parent-of-origin-environment interactions in case-parent triads with or without independent controls.Semantic proximity Read ↗

Family-based analysis of MSX1 haplotypes for association with oral clefts.Semantic proximity Read ↗

Distinguishing the effects of maternal and offspring genes through studies of "case-parent triads".Semantic proximity Read ↗

A new method to account for missing data in case-parent triad studies.Semantic proximity Read ↗

Identification of risk-related haplotypes with the use of multiple SNPs from nuclear families.Semantic proximity Read ↗

Using case-parent triads to estimate relative risks associated with a candidate haplotype.Semantic proximity Read ↗

Inference of gene-environment interaction from heterogeneous case-parent triosSemantic proximity Read ↗

Investigation of maternal effects, maternal-fetal interactions and parent-of-origin effects (imprinting), using mothers and their offspring.Semantic proximity Read ↗

Using cases and parents to study multiplicative gene-by-environment interaction.Semantic proximity Read ↗

Gene-methylation interactions: Discovering region-wise DNA methylation levels that modify SNP-associated disease riskSemantic proximity Read ↗

Genetic Interactions in Nonsyndromic Orofacial Clefts in Europe-EUROCRAN Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.