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Article

PD-1 deficiency results in the development of fatal myocarditis in MRL mice.

International immunology - 1 Jun 2010

Wang Jian, Okazaki Il-Mi, Yoshida Taku, Chikuma Shunsuke, Kato Yu, Nakaki Fumio, Hiai Hiroshi, Honjo Tasuku, Okazaki Taku

Abstract excerpt

The deficiency of programmed cell death 1 (PD-1, Pdcd1), a negative immuno-receptor belonging to the CD28/cytotoxic T lymphocyte antigen 4 (CTLA-4) family, can support various tissue-specific autoimmune conditions. Here, we analyzed the effect of PD-1 deficiency in MRL mice that is genetically predisposed to systemic autoimmunity. MRL-Pdcd1(-)(/-) mice developed a fatal myocarditis, which is reminiscent of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20410257
DOI: 10.1093/intimm/dxq026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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