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PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease

6 Dec 2017

Abstract excerpt

Abstract Effector memory T cells (TEM) are less capable of inducing graft-versus-host disease (GVHD) compared with naive T cells (TN). Previously, in the TS1 TCR transgenic model of GVHD, wherein TS1 CD4 cells specific for a model minor histocompatibility Ag (miHA) induce GVHD in miHA-positive recipients, we found that cell-intrinsic properties of TS1 TEM reduced their GVHD potency relative to TS1 TN....

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PMID: 29212909
DOI: 10.4049/jimmunol.1701076

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