Article
Myosin-primed tolerogenic dendritic cells ameliorate experimental autoimmune myocarditis.
Cardiovascular research - 1 Feb 2014
Lee Jun-Ho, Kim Tae-Hoon, Park Hyo Eun, Lee Eun Gae, Jung Nam-Chul, Song Jie-Young, Seo Han Geuk, Seung Ki-Bae, Chang Kiyuk, Lim Dae-Seog
Abstract excerpt
AIMS: Autoimmunity plays an important role in the pathogenesis of viral myocarditis and giant cell myocarditis. Experimental autoimmune myocarditis (EAM) is a mouse model of myocarditis that is induced by cardiac myosin. Tolerogenic dendritic cells (tDCs) are used as anti-inflammatory and immunosuppressive targets in a number of autoimmune disease models, but their effect on EAM has not been addressed. The aim of...
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