Article
Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice.
Cell death and differentiation - 1 Mar 2017
Anstee Natasha S, Vandenberg Cassandra J, Campbell Kirsteen J, Hughes Peter D, O'Reilly Lorraine A, Cory Suzanne
Abstract excerpt
Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals, there are two converging apoptosis pathways: the 'extrinsic' pathway, which is triggered by engagement of cell surface 'death receptors' such as Fas/APO-1; and the 'intrinsic' pathway, which is triggered by diverse cellular stresses, and is regulated by pro-survival and pro-apoptotic members...
Topics
- Animals
- Autoantibodies
- Autoimmune Diseases
- B-Lymphocytes
- Female
- Immunoglobulin G
- Kaplan-Meier Estimate
- Kidney Diseases
- Lymph Nodes
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred MRL lpr
- Mice, Transgenic