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Article

Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2008

Lucas Julie A, Menke Julia, Rabacal Whitney A, Schoen Frederick J, Sharpe Arlene H, Kelley Vicki R

Abstract excerpt

MRL/MpJ-Fas(lpr) (MRL-Fas(lpr)) mice develop a spontaneous T cell and macrophage-dependent autoimmune disease that shares features with human lupus. Interactions via the programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway down-regulate immune responses and provide a negative regulatory checkpoint in mediating tolerance and autoimmune disease. Therefore, we tested the hypothesis that the PD-1/PD-L1...

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Identifiers

PMID: 18684942
DOI: 10.4049/jimmunol.181.4.2513
PMCID: PMC2587295

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