Article
Generation of humanized mice susceptible to peptide-induced inflammatory heart disease.
Circulation - 13 Apr 1999
Bachmaier K, Neu N, Yeung R S, Mak T W, Liu P, Penninger J M
Abstract excerpt
BACKGROUND: Dilated cardiomyopathy (DCM) is a major cause of sudden cardiac death. In certain mouse major histocompatibility complex (MHC) backgrounds, myocarditis and inflammatory cardiomyopathy can be triggered by immunization with heart muscle-specific proteins. Similarly, chronic heart disease in humans has been linked to certain HLA alleles, such as HLA-DQ6. However, there is no experimental evidence showing...
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