Article

αGalCer/CD1d treatment induces pro-inflammatory iNKT1-associated immune responses without aggravating doxorubicin-induced cardiotoxicity

2025-09-21

Abstract excerpt

Invariant natural killer T (iNKT) cells are a unique subset of innate immune cells activated by T cell receptor (TCR) signaling through CD1d molecules presenting lipid antigens. By localizing to specific tissues, iNKT cells play critical roles in maintaining homeostasis and regulating pathophysiology, making them attractive therapeutic targets for inflammatory diseases. However, their frequency in the heart and po...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1ed50b9e-7390-595f-93df-61d2450562f7
DOI: 10.1101/2025.09.18.676932

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

αGalCer/CD1d treatment induces pro-inflammatory iNKT1-associated immune responses without aggravating doxorubicin-induced cardiotoxicityDOI 10.1101/2025.09.18.676932Read

Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor–Induced MyocarditisSemantic proximity Read

Glucagon-like peptide-1(GLP-1) Prevents Doxorubicin-Induced Cardiotoxicity by Regulating Macrophage PolarizationSemantic proximity Read

Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.Semantic proximity Read

Cytotoxic CD4+ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected heartsSemantic proximity Read

Cytotoxic CD4 <sup>+</sup> T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate <i>Trypanosoma cruzi</i> -infected heartsSemantic proximity Read

Unique Phenotypes of Heart Resident Type 2 Innate Lymphoid Cells.Semantic proximity Read

Upregulation of Biomarker Limd1 Was Correlated with Immune Infiltration in Doxorubicin-Related CardiotoxicitySemantic proximity Read

NLRP3 inflammasome regulates doxorubicin-induced cardiotoxicity by modulating the abundance of gut microbiotaSemantic proximity Read

Autoimmune cardiac-specific T cell responses in dilated cardiomyopathy.Semantic proximity Read

Therapeutic targeting of innate immunity in the failing heartSemantic proximity Read

Pathologic T-cell response in ischaemic failing hearts elucidated by T-cell receptor sequencing and phenotypic characterizationSemantic proximity Read

Revolutionizing cardiac fibrosis treatment: the potential of personalized CAR T-cell therapySemantic proximity Read