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Article

COMT genotype and cognitive function: an 8-year longitudinal study in white and black elders.

Neurology - 20 Apr 2010

Fiocco A J, Lindquist K, Ferrell R, Li R, Simonsick E M, Nalls M, Harris T B, Yaffe K

Abstract excerpt

OBJECTIVE: Catechol-O-methyltransferase (COMT), an enzyme that catalyzes the degradation of dopamine, is necessary for cognitive function. Few studies have examined the prospective association between COMT (val(158)met) genotype and cognition in older adults. METHODS: We assessed a biracial cohort of 2,858 elderly subjects without dementia who were followed for 8 years. The Modified Mini-Mental State Examination...

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Source

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Identifiers

PMID: 20404311
DOI: 10.1212/WNL.0b013e3181d9edba
PMCID: PMC2860484

Genes

COMT
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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