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Article

Association study of a functional catechol-o-methyltransferase polymorphism and cognitive function in patients with dementia.

Collegium antropologicum - 1 Jan 2011

Nedić Gordana, Borovecki Fran, Klepac Natasa, Mubrin Zdenko, Hajnsek Sanja, Nikolac Matea, Muck-Seler Dorotea, Pivac Nela

Abstract excerpt

A functional catechol-o-methyltransferase (COMT Val158/108Met) polymorphism, a valine (Val) to methionine (Met) substitution, has been associated with cognitive processing in the normal brain, older age, mild cognitive impairment and in various dementias. COMT is involved in the breakdown of dopamine and other catecholamines, especially in the frontal cortex; hence the carriers of Met allele, with the lower...

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Source

Identifiers

PMID: 21648315

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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