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Article

COMT genotype and cognitive ability: a longitudinal aging study.

Neuroscience letters - 21 Jun 2007

Starr John M, Fox Helen, Harris Sarah E, Deary Ian J, Whalley Lawrence J

Abstract excerpt

Dopaminergic neurotransmission in the pre-frontal cortex (PFC) contributes to individual cognitive differences in animals and humans. Catechol-O-methyltransferase (COMT) influences dopamine concentration in the PFC. Functional variation in the human COMT gene occurs at a single nucleotide polymorphism (SNP)--472G>A--that results in a valine (Val) to methionine (Met) amino acid substitution (Val158Met). The...

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Source

Identifiers

PMID: 17548151
DOI: 10.1016/j.neulet.2007.05.023

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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