Article
The TGFBR1*6A allele is not associated with susceptibility to colorectal cancer in a Spanish population: a case-control study.
BMC cancer - 18 Jun 2009
Castillejo Adela, Mata-Balaguer Trinidad, Montenegro Paola, Ochoa Enrique, Lázaro Rafael, Martínez-Cantó Ana, Castillejo María-Isabel, Guarinos Carla, Barberá Víctor-Manuel, Guillén-Ponce Carmen, Carrato Alfredo, Soto José-Luís
Abstract excerpt
BACKGROUND: TGF-beta receptor type I is a mediator of growth inhibitory signals. TGFBR1*6A (rs11466445) is a common polymorphic variant of the TGF-beta receptor I gene and has been associated with tumour susceptibility. Nevertheless, the role of this polymorphism as a risk factor for colorectal cancer is controversial. The aim of this study was to assess the association between TGFBR1*6A and colorectal cancer,...
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