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Article

Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression.

Genes, chromosomes & cancer - 1 Mar 2010

Försti Asta, Li Xuchen, Wagner Kerstin, Tavelin Björn, Enquist Kerstin, Palmqvist Richard, Altieri Andrea, Hallmans Göran, Hemminki Kari, Lenner Per

Abstract excerpt

Transforming growth factor beta1 (TGFB1) acts as a growth inhibitor of normal colonic epithelial cells, however, as a tumor promoter of colorectal cancer (CRC) cells. To explore the association between genetic polymorphisms in the TGFB1 pathway and CRC susceptibility and clinical outcome, we carried out a case-control study on a Swedish population of 308 CRC cases and 585 age- and gender-matched controls. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19998449
DOI: 10.1002/gcc.20738

Genes

TGFB1
BAMBI
FURIN
LTBP4
TGFBR1
THBS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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