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Article

TGFBR1 variants TGFBR1(*)6A and Int7G24A are not associated with an increased familial colorectal cancer risk.

British journal of cancer - 19 May 2009

Skoglund Lundin J, Vandrovcova J, Song B, Zhou X, Zelada-Hedman M, Werelius B, Houlston R S, Lindblom A

Abstract excerpt

Variants of the transforming growth factor-beta receptor type 1 (TGFBR1) gene, TGFBR1*6A and Int7G24A, have been suggested to act as low-penetrance tumour susceptibility alleles with TGFBR1*6A being causally responsible for some cases of familial colorectal cancer (CRC). We performed a case-control study of 262 unrelated familial CRC cases; 83 hereditary non-polyposis colorectal cancer (HNPCC) and 179 non-HNPCC....

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Source

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Identifiers

PMID: 19401691
DOI: 10.1038/sj.bjc.6605054
PMCID: PMC2696757

Genes

TGFBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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TGFBR1 variants TGFBR1(*)6A and Int7G24A are not associated with an increased familial colorectal cancer risk.PMID 19401691Read ↗

Lack of an association between the TGFBR1*6A variant and colorectal cancer risk.Semantic proximity Read ↗

TGFBR1(*)6A and Int7G24A variants of transforming growth factor-beta receptor 1 in Swedish familial and sporadic breast cancer.Semantic proximity Read ↗

The TGFBR1*6A allele is not associated with susceptibility to colorectal cancer in a Spanish population: a case-control study.Semantic proximity Read ↗

Little evidence for association between the TGFBR1*6A variant and colorectal cancer: a family-based association study on non-syndromic family members from Australia and Spain.Semantic proximity Read ↗

The TGFBR1*6A/9A polymorphism is not associated with differential risk of breast cancer.Semantic proximity Read ↗

Comprehensive assessment of variation at the transforming growth factor beta type 1 receptor locus and colorectal cancer predisposition.Semantic proximity Read ↗

The association of polymorphisms on TGFBR1 and colorectal cancer risk: a meta-analysis.Semantic proximity Read ↗

Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia?Semantic proximity Read ↗

TGFBR1*6A polymorphism in sporadic and familial colorectal Carcinoma: a case-control study and systematic literature review.Semantic proximity Read ↗

Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC).Semantic proximity Read ↗

The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study.Semantic proximity Read ↗

TGFBR1*6A and cancer risk: a meta-analysis of seven case-control studies.Semantic proximity Read ↗

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