Article
Little evidence for association between the TGFBR1*6A variant and colorectal cancer: a family-based association study on non-syndromic family members from Australia and Spain.
BMC cancer - 1 Jul 2014
Ross Jason P, Lockett Linda J, Tabor Bruce, Saunders Ian W, Young Graeme P, Macrae Finlay, Blanco Ignacio, Capella Gabriel, Brown Glenn S, Lockett Trevor J, Hannan Garry N
Abstract excerpt
BACKGROUND: Genome-wide linkage studies have identified the 9q22 chromosomal region as linked with colorectal cancer (CRC) predisposition. A candidate gene in this region is transforming growth factor β receptor 1 (TGFBR1). Investigation of TGFBR1 has focused on the common genetic variant rs11466445, a short exonic deletion of nine base pairs which results in truncation of a stretch of nine alanine residues to...
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