Induction of mutations by N-acetoxy-N-acetyl-2-aminofluorene modified M13 viral DNA.

doi:10.1093/carcin/12.5.819

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Article

Induction of mutations by N-acetoxy-N-acetyl-2-aminofluorene modified M13 viral DNA.

Carcinogenesis - 1 May 1991

Gupta P K, Pandrangi R G, Lee M S, King C M

Abstract excerpt

The specificity of N-(deoxyguanosin-8-yl)-N-acetyl-2-aminofluorene (G-8-AAF) adducts in double-stranded DNAs from M13mp8 and M13mp9 bacteriophage was determined following transfection of modified DNA with multiple adducts into competent JM103 cells. Mutant phages were selected by phenotypic scree...

Topics

2-Acetylaminofluorene
Acetoxyacetylaminofluorene
Base Sequence
Coliphages
DNA, Viral
Deoxyguanosine
Frameshift Mutation
Molecular Sequence Data
Mutation
Plasmids
SOS Response, Genetics
Transfection

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