Article
Induction of -2 frameshift mutations within alternating GC sequences by carcinogens that bind to the C8 position of guanine residues: development of a specific mutation assay.
Molecular & general genetics : MGG - 1 May 1990
Bintz R, Fuchs R P
Abstract excerpt
Using a forward mutation assay we have previously found that N-2-acetylaminofluorene (AAF), a strong chemical carcinogen, induces a majority of frameshift mutations located at specific sequences called mutation hot spots. Among these hot spot sequences, the NarI sequence (GGCGCC), is specific for...
Topics
- 2-Acetylaminofluorene
- Acetoxyacetylaminofluorene
- Base Composition
- Base Sequence
- Carcinogens
- DNA, Bacterial
- Escherichia coli
- Mutagenicity Tests
- Mutation
- Nucleic Acid Conformation
- Plasmids