Mutagenesis by site-specific arylamine adducts in plasmid DNA: enhancing replication of the adducted strand alters mutation frequency.

doi:10.1021/bi00478a007

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Article

Mutagenesis by site-specific arylamine adducts in plasmid DNA: enhancing replication of the adducted strand alters mutation frequency.

Biochemistry - 3 Jul 1990

Reid T M, Lee M S, King C M

Abstract excerpt

Site specifically modified plasmids were used to determine the mutagenic effects of single arylamine adducts in bacterial cells. A synthetic heptadecamer bearing a single N-(guanin-8-yl)-2-aminofluorene (AF) or N-(guanin-8-yl)-2-(acetylamino)fluorene (AAF) adduct was used to introduce the adducts...

Topics

Acetamides
Base Sequence
DNA Damage
DNA Replication
DNA, Bacterial
Escherichia coli
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Plasmids
SOS Response, Genetics
Uracil

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