Induction of mutations by replication of malondialdehyde-modified M13 DNA in Escherichia coli: determination of the extent of DNA modification, genetic requirements for mutagenesis, and types of mutations induced.

doi:10.1093/carcin/16.1.93

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Article

Induction of mutations by replication of malondialdehyde-modified M13 DNA in Escherichia coli: determination of the extent of DNA modification, genetic requirements for mutagenesis, and types of mutations induced.

Carcinogenesis - 1 Jan 1995

Benamira M, Johnson K, Chaudhary A, Bruner K, Tibbetts C, Marnett L J

Abstract excerpt

The mutagenicity of the lipid peroxidation product, malondialdehyde (MDA), was measured in the lacZ alpha forward mutation assay using a recombinant M13 phage, M13MB102. Single-stranded M13MB102 DNA was reacted with MDA at neutral pH and the modified DNA was transformed into strains of Escherichia coli induced for the SOS response. Increasing concentrations of MDA led to an increase in lacZ alpha-mutations...

Topics

Bacteriophage M13
Base Composition
Base Sequence
DNA Adducts
DNA Replication
DNA, Single-Stranded
DNA, Viral
Escherichia coli
Kinetics
Lipid Peroxidation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Malondialdehyde

Molecular Sequence Data

Mutagenesis

Mutation

Phenotype

Transformation, Genetic

Source

Open in PubMed

Identifiers

PMID: 7834810
DOI: 10.1093/carcin/16.1.93

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7834810-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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