Monofunctional adenine N-3 adducts of melphalan: occurrence at a mutational hotspot sequence and resistance to removal by AlkA protein.

Article

Monofunctional adenine N-3 adducts of melphalan: occurrence at a mutational hotspot sequence and resistance to removal by AlkA protein.

Environmental and molecular mutagenesis - 1 Jan 1998

Charles K, Bauer G B, Povirk L F

Abstract excerpt

Previous work showed that a CTAAA sequence in the supF gene of the shuttle plasmid pZ189 was a hotspot for mutagenesis by the aromatic nitrogen mustards melphalan and chlorambucil, and indirect evidence suggested adenine N-3 adducts as premutagenic lesions. In order to characterize the adducts fo...

Topics

Base Sequence
DNA Adducts
Escherichia coli
Melphalan
Mutation
NADH, NADPH Oxidoreductases

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