Article
SOS-dependent replication past a single trans-syn T-T cyclobutane dimer gives a different mutation spectrum and increased error rate compared with replication past this lesion in uninduced cells.
Journal of bacteriology - 1 Apr 1990
Banerjee S K, Borden A, Christensen R B, LeClerc J E, Lawrence C W
Abstract excerpt
We have transfected SOS-induced and uninduced cells of a uvrA6 strain of Escherichia coli with single-stranded M13mp7-based vectors that carried a single trans-syn T-T cyclobutane dimer at a unique site. Unlike constructs carrying the cis-syn isomer of this lesion, these vectors could be replicat...
Topics
- Base Sequence
- Chromosome Deletion
- DNA Damage
- DNA Repair
- DNA Replication
- DNA-Directed DNA Polymerase
- Escherichia coli
- Genetic Techniques
- Genetic Vectors
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Pyrimidine Dimers
- SOS Response, Genetics