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Article

Mutation frequency and spectrum resulting from a single abasic site in a single-stranded vector.

Nucleic acids research - 25 Apr 1990

Lawrence C W, Borden A, Banerjee S K, LeClerc J E

Abstract excerpt

We have investigated the mutagenic properties of an abasic site in DNA by transfecting SOS-induced and uninduced cells of E. coli with a single-stranded M13mp7-based vector that carries a single example of this lesion at one or other of two unique and adjacent sites. Random samples of progeny phage were sequenced to determine the nature of the replication events that occurred at and around these locations. 5% to...

Topics

Bacteriophages
Base Sequence
DNA Replication
DNA, Single-Stranded
Escherichia coli
Genetic Vectors
Molecular Sequence Data
Mutation
SOS Response, Genetics
Transfection

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Identifiers

PMID: 2186377
DOI: 10.1093/nar/18.8.2153
PMCID: PMC330696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2186377-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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