Position of a single acetylaminofluorene adduct within a mutational hot spot is critical for the related mutagenic event.

Abstract excerpt

2-Acetylaminofluorene, a potent rat liver carcinogen, which binds primarily to C8 of guanines, has been shown to induce mainly frameshift mutations in the bacteria Escherichia coli. Mutations occur at specific sequences, known as mutation hot spots, of which two types may be considered. First, repetitive sequences, where deletions of a single unit occur (GGGGG----GGGG). Second, the so-called NarI site,...

Topics

• 2-Acetylaminofluorene
• Base Sequence
• DNA Damage
• DNA, Bacterial
• Escherichia coli
• Genes, Bacterial
• Molecular Sequence Data
• Mutation
• Nucleic Acid Conformation
• Plasmids