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Article

Mutations induced by aromatic amine DNA adducts in pBR322.

Carcinogenesis - 1 May 1994

Melchior W B, Marques M M, Beland F A

Abstract excerpt

A 276 bp region from the tetracycline resistance gene of the plasmid pBR322 was modified with 2-acetylaminofluorene (AAF), 2-aminofluorene (AF), 4-aminobiphenyl (ABP), N'-acetylbenzidine or 1-aminopyrene (AP) in order to determine the effect of adduct structure upon mutation induction. Each modification reaction gave one major adduct and these adducts had chromatographic properties, as determined by...

Topics

2-Acetylaminofluorene
Amines
Amino Acid Sequence
Aminobiphenyl Compounds
Benzidines
DNA
Deoxyguanosine
Escherichia coli
Fluorenes
Hydrocarbons
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Pyrenes

Tetracycline Resistance

Transfection

Source

Identifiers

PMID: 8200092
DOI: 10.1093/carcin/15.5.889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8200092-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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