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Article

Induced mutations in M13mp2 phage DNA exposed to N-nitrosopyrrolidine with UVA irradiation.

Environmental and molecular mutagenesis - 1 Jan 1999

Arimoto-Kobayashi S, Inada N, Anma N, Shimada H, Hayatsu H

Abstract excerpt

It is known that N-nitrosopyrrolidine (NPYR), a carcinogen in rodents, is metabolically activated by microsomal cytochrome P450 to form an alpha-hydroxylated derivative, which induces mutations. The mutations have been demonstrated by use of Salmonella typhimurium and Escherichia coli. We discovered directly acting mutagenicity of NPYR plus ultraviolet light-A (UVA) in bacteria and phage. With an...

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PMID: 10462720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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