Article
Zinc inhibition of monomeric and dimeric proton channels suggests cooperative gating.
The Journal of physiology - 1 May 2010
Musset Boris, Smith Susan M E, Rajan Sindhu, Cherny Vladimir V, Sujai Sukrutha, Morgan Deri, DeCoursey Thomas E
Abstract excerpt
Voltage-gated proton channels are strongly inhibited by Zn(2+), which binds to His residues. However, in a molecular model, the two externally accessible His are too far apart to coordinate Zn(2+). We hypothesize that high-affinity Zn(2+) binding occurs at the dimer interface between pairs of His residues from both monomers. Consistent with this idea, Zn(2+) effects were weaker in monomeric channels. Mutation of...
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