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Article

Intra- and intersubunit cooperativity in activation of BK channels by Ca2+.

The Journal of general physiology - 1 Oct 2006

Qian Xiang, Niu Xiaowei, Magleby Karl L

Abstract excerpt

The activation of BK channels by Ca(2+) is highly cooperative, with small changes in intracellular Ca(2+) concentration having large effects on open probability (Po). Here we examine the mechanism of cooperative activation of BK channels by Ca(2+). Each of the four subunits of BK channels has a large intracellular COOH terminus with two different high-affinity Ca(2+) sensors: an RCK1 sensor (D362/D367) located on...

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Identifiers

PMID: 17001085
DOI: 10.1085/jgp.200609486
PMCID: PMC2151572

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Intra- and intersubunit cooperativity in activation of BK channels by Ca2+.PMID 17001085Read ↗

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