Article
Molecular mechanism of Zn2+ inhibition of a voltage-gated proton channel.
Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2016
Qiu Feng, Chamberlin Adam, Watkins Briana M, Ionescu Alina, Perez Marta Elena, Barro-Soria Rene, González Carlos, Noskov Sergei Y, Larsson H Peter
Abstract excerpt
Voltage-gated proton (Hv1) channels are involved in many physiological processes, such as pH homeostasis and the innate immune response. Zn2+ is an important physiological inhibitor of Hv1. Sperm cells are quiescent in the male reproductive system due to Zn2+ inhibition of Hv1 channels, but become active once introduced into the low-Zn2+-concentration environment of the female reproductive tract. How Zn2+...
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