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Article

Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanism.

Proceedings of the National Academy of Sciences of the United States of America - 7 Feb 2006

Leng Qiang, MacGregor Gordon G, Dong Ke, Giebisch Gerhard, Hebert Steven C

Abstract excerpt

The tetrameric K channel ROMK provides an important pathway for K secretion by the mammalian kidney, and the gating of this channel is highly sensitive to changes in cytosolic pH. Although charge-charge interactions have been implicated in pH sensing by this K channel tetramer, the molecular mechanism linking pH sensing and the gating of ion channels is poorly understood. The x-ray crystal structure KirBac1.1, a...

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Identifiers

PMID: 16446432
DOI: 10.1073/pnas.0510610103
PMCID: PMC1413660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanism.PMID 16446432Read ↗

A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating.Semantic proximity Read ↗

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Molecular mechanism of a COOH-terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation.Semantic proximity Read ↗

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Functional and structural characterization of PKA-mediated pHi gating of ROMK1 channels.Semantic proximity Read ↗

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