Mg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevated.

Abstract excerpt

BK channels are activated by intracellular Ca(2+) and Mg(2+) as well as by depolarization. Such activation is possible because each of the four subunits has two high-affinity Ca(2+) sites, one low-affinity Mg(2+) site, and a voltage sensor. This study further investigates the mechanism of Mg(2+) activation by using single-channel recording to determine separately the action of Mg(2+) on the open and closed states...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ion Channel Gating
• Share to Kinetics
• Share to Large-Conductance Calcium-Activated Potassium Channels