Article
Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jun 2008
Lee Seok-Yong, Letts James A, Mackinnon Roderick
Abstract excerpt
In voltage-gated Na(+), K(+), and Ca(2+) channels, four voltage-sensor domains operate on a central pore domain in response to membrane voltage. In contrast, the voltage-gated proton channel (Hv) contains only a voltage-sensor domain, lacking a separate pore domain. The subunit stoichiometry and organization of Hv has been unknown. Here, we show that human Hv1 forms a dimer in the membrane and define regions that...
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