Article
Ionic interactions of Ba2+ blockades in the MthK K+ channel.
The Journal of general physiology - 1 Aug 2014
Guo Rui, Zeng Weizhong, Cui Hengjun, Chen Liping, Ye Sheng
Abstract excerpt
The movement and interaction of multiple ions passing through in single file underlie various fundamental K(+) channel properties, from the effective conduction of K(+) ions to channel blockade by Ba(2+) ions. In this study, we used single-channel electrophysiology and x-ray crystallography to probe the interactions of Ba(2+) with permeant ions within the ion conduction pathway of the MthK K(+) channel. We found...
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