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Article

Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface.

Journal of molecular biology - 16 Apr 2021

Mersch Kacey, Ozturk Tugba N, Park Kunwoong, Lim Hyun-Ho, Robertson Janice L

Abstract excerpt

CLC-ec1 is a Cl-/H+ antiporter that forms stable homodimers in lipid bilayers, with a free energy of -10.9 kcal/mol in 2:1 POPE/POPG lipid bilayers. The dimerization interface is formed by four transmembrane helices: H, I, P and Q, that are lined by non-polar side-chains that come in close contact, yet it is unclear as to whether their interactions drive dimerization. To investigate whether non-polar side-chains...

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Identifiers

PMID: 33617898
DOI: 10.1016/j.jmb.2021.166886
PMCID: PMC8734038

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