Article
Assessing interactions between HLA-DRB1*15 and infectious mononucleosis on the risk of multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Sept 2013
Disanto Giulio, Hall Carolina, Lucas Robyn, Ponsonby Anne-Louise, Berlanga-Taylor Antonio J, Giovannoni Gavin, Ramagopalan Sreeram V
Abstract excerpt
Gene-environment interactions may shed light on the mechanisms underlying multiple sclerosis (MS). We pooled data from two case-control studies on incident demyelination and used different methods to assess interaction between HLA-DRB1*15 (DRB1-15) and history of infectious mononucleosis (IM). Individuals exposed to both factors were at substantially increased risk of disease (OR=7.32, 95% CI=4.92-10.90). In...
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