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Article

DRB1-environment interactions in multiple sclerosis etiology: results from two Swedish case-control studies.

Journal of neurology, neurosurgery, and psychiatry - 1 Jul 2021

Hedström Anna Karin, Hillert Jan, Brenner Nicole, Butt Julia, Waterboer Tim, Strid Pernilla, Kockum Ingrid, Olsson Tomas, Alfredsson Lars

Abstract excerpt

OBJECTIVE: We aimed to investigate the influence of environmental risk factors for multiple sclerosis (MS) in different genetic contexts, and study if interactions between environmental factors and human leucocyte antigen (HLA) genes differ in magnitude according to heterozygocity and homozygocity for HLA-DRB1*15:01. METHODS: Using population-based case-control studies (6985 cases, 6569 controls), subjects with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33687974
DOI: 10.1136/jnnp-2020-325676
PMCID: PMC8223646

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