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Article

A Child's HLA-DRB1 genotype increases maternal risk of systemic lupus erythematosus.

Journal of autoimmunity - 1 Nov 2016

Cruz Giovanna I, Shao Xiaorong, Quach Hong, Ho Kimberly A, Sterba Kirsten, Noble Janelle A, Patsopoulos Nikolaos A, Busch Michael P, Triulzi Darrell J, Wong Wendy S W, Solomon Benjamin D, Niederhuber John E, Criswell Lindsey A, Barcellos Lisa F

Abstract excerpt

Systemic lupus erythematosus (SLE) disproportionately affects women of reproductive age. During pregnancy, women are exposed to various sources of fetal material possibly constituting a significant immunologic exposure relevant to the development of SLE. The objective of this study was to investigate whether having any children who carry DRB1 alleles associated with SLE increase the risk of maternal SLE. This...

Topics

Adult
Alleles
Autoantibodies
Case-Control Studies
Child
Female
Genetic Predisposition to Disease
Genotype
HLA-DRB1 Chains
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lupus Erythematosus, Systemic

Maternal-Fetal Exchange

Middle Aged

Odds Ratio

Pregnancy

Source

Open in PubMed Open full text

Identifiers

PMID: 27388144
DOI: 10.1016/j.jaut.2016.06.017
PMCID: PMC5079818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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