Additive effect of the HLA-DR15 haplotype on susceptibility to multiple sclerosis.

doi:10.1177/135245850100700203

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Article

Additive effect of the HLA-DR15 haplotype on susceptibility to multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Apr 2001

Rasmussen H B, Kelly M A, Clausen J

Abstract excerpt

Multiple sclerosis (MS) has been associated with the human leukocyte antigen DR15 allele in Caucasians of North and Central European origin. However, the relative effect of the DR15 homozygous and the DR15 heterozygous genotypes on the disease susceptibility is unclear. Based upon results from three North European studies we have examined this by meta-analysis. Our results suggested that the effect of the...

Topics

Genetic Predisposition to Disease
HLA-DR Antigens
HLA-DR Serological Subtypes
Haplotypes
Humans
Multiple Sclerosis

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Open in PubMed

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PMID: 11424637
DOI: 10.1177/135245850100700203

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