Article
Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients.
Annals of neurology - 1 Jul 2003
Alizadeh Mehdi, Babron Marie-Claude, Birebent Brigitte, Matsuda Fumihiko, Quelvennec Erwann, Liblau Roland, Cournu-Rebeix Isabelle, Momigliano-Richiardi Patricia, Sequeiros Jorge, Yaouanq Jacqueline, Genin Emmanuelle, Vasilescu Alexandre, Bougerie Héloise, Trojano Maria, Martins Silva Berta, Maciel Patricia, Clerget-Darpoux Françoise, Clanet Michel, Edan Gilles, Fontaine Bertrand, Semana Gilbert
Abstract excerpt
Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in...
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