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Article

TOP2 gene disruption reduces drug susceptibility by increasing intracellular ergosterol biosynthesis in Candida albicans.

Journal of medical microbiology - 1 Jul 2010

Zheng Hao, Jiang Yuan-Ying, Wang Yan, Jia Xin-Ming, Yan Tian-Hua, Gao Ping-Hui, Yan Lan, Jiang Ling-Huo, Ji Hui, Cao Yong-Bing

Abstract excerpt

In this study the role of the TOP2 gene in fungal drug susceptibility was investigated by disrupting and overexpressing the gene in Candida albicans. MIC determination and a spot assay showed that a top2Delta/Delta null mutant (strain T2bc) was more resistant to the antifungals tested than the wild-type (strain CAI4). Real-time RT-PCR and rhodamine 6G efflux examination showed that TOP2 did not influence the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20223895
DOI: 10.1099/jmm.0.018325-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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