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Article

Erg251 has complex and pleiotropic effects on sterol composition, azole susceptibility, filamentation, and stress response phenotypes.

PLoS pathogens - 1 Jul 2024

Zhou Xin, Hilk Audrey, Solis Norma V, Pereira De Sa Nivea, Hogan Bode M, Bierbaum Tessa A, Del Poeta Maurizio, Filler Scott G, Burrack Laura S, Selmecki Anna

Abstract excerpt

Ergosterol is essential for fungal cell membrane integrity and growth, and numerous antifungal drugs target ergosterol. Inactivation or modification of ergosterol biosynthetic genes can lead to changes in antifungal drug susceptibility, filamentation and stress response. Here, we found that the ergosterol biosynthesis gene ERG251 is a hotspot for point mutations during adaptation to antifungal drug stress within...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39078851
DOI: 10.1371/journal.ppat.1012389
PMCID: PMC11315318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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