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Article

Genomic Profiling of the Response of Candida albicans to Itraconazole Treatment Using a DNA Microarray

1 Jun 2001

Abstract excerpt

The application of genome-wide expression profiling to determine how drugs achieve their therapeutic effect has provided the pharmaceutical industry with an exciting new tool for drug mode-of-action studies. We used DNA chip technology to study cellular responses to perturbations of ergosterol biosynthesis caused by the broad-spectrum antifungal agent itraconazole. Simultaneous examination of over 6,600 Candida...

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Identifiers

PMID: 11353609
DOI: 10.1128/aac.45.6.1660-1670.2001

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